The glutathione thiyl radical does not react with nitrogen monoxide

Abstract

Laser flash photolysis experiments shows that the rate constant for the reaction of the glutathione thiyl radical with nitrogen monoxide to give S-nitrosoglutathione is lower than 2.8 ± 0.6 × 107 M-1 s-1. The conversion of the thiyl radical to its carbon-centred form at 103 s-1 exceeds the formation of S-nitrosoglutathione when physiological concentrations of nitrogen monoxide are taken into account. © 2007 Elsevier Inc. All rights reserved.