Glycoxidation and lipoperoxidation in the collagen of the myocardium in hemodialysis patients

  • Moh A
  • Sakata N
  • Noma A
 et al. 
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Objective: The purpose of this study is to examine the glycoxidation and lipoperoxidation products in the collagen of the myocardium in hemodialysis patients (HD group) and age-matched control subjects. Subjects and methods: Cardiac samples from 15 autopsied subjects (HD, n=6; Control, n=9) were sequentially extracted with 0.9% NaCl and collagenase to obtain two fractions (soluble fraction: SF and collagenase soluble fraction: CSF). The glycoxidation and lipoperoxidation products of these two fractions were measured by pentosidine-linked fluorescence (ex: 335/em: 385) and malondialdehyde (MDA)-linked fluorescence (ex: 390/em: 460), respectively. Results: Both pentosidine- and MDA-linked fluorescence were found to have significantly increased more in the collagenase soluble fraction (CSF) extracted form the anterior and posterior wall in HD patients than in the controls (p

Author-supplied keywords

  • Collagen
  • Glycoxidation
  • Hemodialysis
  • Lipoperoxidation
  • Myocardium

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  • A. Moh

  • N. Sakata

  • A. Noma

  • N. Uesugi

  • S. Takebayashi

  • R. Nagai

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