Glycoxidation and lipoperoxidation in the collagen of the myocardium in hemodialysis patients

  • Moh A
  • Sakata N
  • Noma A
 et al. 
  • 3

    Readers

    Mendeley users who have this article in their library.
  • 0

    Citations

    Citations of this article.

Abstract

Objective: The purpose of this study is to examine the glycoxidation and lipoperoxidation products in the collagen of the myocardium in hemodialysis patients (HD group) and age-matched control subjects. Subjects and methods: Cardiac samples from 15 autopsied subjects (HD, n=6; Control, n=9) were sequentially extracted with 0.9% NaCl and collagenase to obtain two fractions (soluble fraction: SF and collagenase soluble fraction: CSF). The glycoxidation and lipoperoxidation products of these two fractions were measured by pentosidine-linked fluorescence (ex: 335/em: 385) and malondialdehyde (MDA)-linked fluorescence (ex: 390/em: 460), respectively. Results: Both pentosidine- and MDA-linked fluorescence were found to have significantly increased more in the collagenase soluble fraction (CSF) extracted form the anterior and posterior wall in HD patients than in the controls (p

Author-supplied keywords

  • Collagen
  • Glycoxidation
  • Hemodialysis
  • Lipoperoxidation
  • Myocardium

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • A. Moh

  • N. Sakata

  • A. Noma

  • N. Uesugi

  • S. Takebayashi

  • R. Nagai

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free