Growth-associated protein-43 is increased in cerebrum of immature rats following induction of hydrocephalus

Citations of this article
Mendeley users who have this article in their library.
Get full text


Hydrocephalus is associated with gradual progressive impairment and destruction of cerebral axons and neurons. Growth associated protein-43 appears to be permissive for neuro-axonal regeneration and synaptic remodeling. Hydrocephalus was induced in three-week-old rats by injection of kaolin into the cisterna magna. Compared to controls, cerebral growth- associated protein-43 messenger RNA was significantly up-regulated one week after kaolin injection and the overall cerebral growth-associated protein-43 protein level was significantly higher at four weeks when the ventricles were severely enlarged. One and three weeks after kaolin injection, growth- associated protein-43-like immunoreactivity was increased in periventricular axons, and also in the cerebral cortex at three weeks. Hydrocephalic rats that had been treated by shunting after one week, exhibited growth- associated protein-43 messenger RNA and protein levels intermediate between hydrocephalic rats and control rats. The increase in periventricular axon growth-associated protein-43, early in the course of experimental hydrocephalus, suggests that through early intervention there may be a chance for preventing or reversing the axonal injury. Cortical expression of growth associated protein-43 suggests that an alteration in synaptogenesis may also occur.




Zhang, Y. W., & Del Bigio, M. R. (1998). Growth-associated protein-43 is increased in cerebrum of immature rats following induction of hydrocephalus. Neuroscience, 86(3), 847–854.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free