Hydroxyl radical generation after the third hour following ischemia contributes to brain damage

  • Takamatsu H
  • Kondo K
  • Ikeda Y
 et al. 
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Abstract

The purpose of the present study was to determine after what time period hydroxyl radical formation contributes most to ischemic brain damage in focal ischemia, using a hydroxyl radical scavenger, EPC-K1, l-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl-tridecyl)-2H-1-benzopyran-6yl-hydrogen phosphate] potassium salt. Focal ischemia was produced by thrombotic occlusion of the left middle cerebral artery in rats. After evaluation of the pharmacokinetics of EPC-K1in the brain tissue and plasma following 10 mg/kg intravenous bolus treatment of conscious rats, we investigated the neuroprotective effect of EPC-K1in the middle cerebral artery occlusion model. A single intravenous bolus of EPC-K1was given immediately, 3 or 6 h after ischemia, and cerebral brain damage was measured 24 h after ischemia. When EPC-K1was injected 3 h after ischemia, a significant (P

Author-supplied keywords

  • Cerebral focal ischemia
  • EPC-K1
  • Hydroxyl radical
  • Middle cerebral artery occlusion
  • Rat
  • Thrombosis middle cerebral artery

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Authors

  • Hiroyuki Takamatsu

  • Kazunao Kondo

  • Yasuhiko Ikeda

  • Kazuo Umemura

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