IBX/TEAB-mediated oxidative dimerization of thioamides: synthesis of 3,5-disubstituted 1,2,4-thiadiazoles

  • Patil P
  • Bhalerao D
  • Dangate P
 et al. 
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Abstract

Thioamides undergo oxidative dimerization on treatment with hypervalent iodine(V)-containing reagents, particularly o-iodoxybenzoic acid (IBX), in the presence of tetraethylammonium bromide (TEAB) to generate 3,5-disubstituted 1,2,4-thiadiazoles in excellent yield. © 2009 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Hypervalent iodine reagents
  • TEAB
  • Thiadiazoles
  • Thioamides
  • o-Iodoxybenzoic acid

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