Influence of carboxylate ions containing polymers on calcification: In vitro study

  • Smetana K
  • Štol M
  • Novák M
 et al. 
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Abstract

Calcification of implant or surrounding tissues represents an important complication of its function. The role of the molecular structure of a model hydrogel on the calcification is studied here in a simple in vitro, cell free system. The results show that - COO-containing polymers have an inhibitory effect on Ca2+crystal formation. This process seems to be unspecific, because the polymers of different structure and origin have an inhibitory effect. However, its efficiency is related to a different extent of Ca2+binding capacity of distinct polymers.

Author-supplied keywords

  • Calcification
  • Extracellular matrix
  • Polyanions
  • Synthetic polymers

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Authors

  • Karel Smetana

  • Miroslav Štol

  • Miloš Novák

  • Jan Daneš

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