Calcification of implant or surrounding tissues represents an important complication of its function. The role of the molecular structure of a model hydrogel on the calcification is studied here in a simple in vitro, cell free system. The results show that - COO-containing polymers have an inhibitory effect on Ca2+crystal formation. This process seems to be unspecific, because the polymers of different structure and origin have an inhibitory effect. However, its efficiency is related to a different extent of Ca2+binding capacity of distinct polymers.
Smetana, K., Štol, M., Novák, M., & Daneš, J. (1996). Influence of carboxylate ions containing polymers on calcification: In vitro study. Biomaterials, 17(16), 1563–1566. https://doi.org/10.1016/0142-9612(95)00345-2