BALB/c mice were given five intraperitoneal (i.p.) injections of lambda carrageenan (CGNA). Following this treatment, the viability, phagocytic capacity, bactericidal activity, interleukin 1 (IL-1)-producing ability and Ia+cell content of the peritoneal plastic-adherent macrophage population was analysed. The present study demonstrates the enhancement of bactericidal activity, inhibition of the augmented Ia+cell content after priming with sheep red bloo cells (SRBC), and impairment of IL-1 production by peritoneal macrophages, although their viability and phagocytic function remained unaltered. © 1989.
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