Influence of carrageenan on peritoneal macrophages

  • Vijayakumar R
  • Palanivel V
  • Muthukkaruppan V
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Abstract

BALB/c mice were given five intraperitoneal (i.p.) injections of lambda carrageenan (CGNA). Following this treatment, the viability, phagocytic capacity, bactericidal activity, interleukin 1 (IL-1)-producing ability and Ia+cell content of the peritoneal plastic-adherent macrophage population was analysed. The present study demonstrates the enhancement of bactericidal activity, inhibition of the augmented Ia+cell content after priming with sheep red bloo cells (SRBC), and impairment of IL-1 production by peritoneal macrophages, although their viability and phagocytic function remained unaltered. © 1989.

Author-supplied keywords

  • CGNA, Carrageenan(lambda)
  • Carrageenan
  • Ia, immune response-associated antigen (IA/IE)
  • Immuno-suppression
  • Indo, indomethacin
  • LPS, lipopolysaccharide
  • Macrophage
  • Modulation
  • PEC, peritoneal exudate cells
  • PG
  • prostaglandin

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Authors

  • R. K. Vijayakumar

  • V. Palanivel

  • V. R. Muthukkaruppan

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