The effect of isatin (indole-2,3-dione) on d-glucose uptake in rat intestine was studied. Isatin at 1-6 mm concentrations appreciably depressed sodium-dependent glucose uptake, but had no effect on sodium-independent sugar uptake in intestine. Kinetic studies revealed isatin to be a noncompetitive inhibitor of sugar uptake. The inhibitory constant (Ki) was of the order of 7.80 mm. © 1983.
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