Localization of the antinociceptive action of morphine in primate brain

  • Pert A
  • Yaksh T
  • 5

    Readers

    Mendeley users who have this article in their library.
  • 58

    Citations

    Citations of this article.

Abstract

Microinjections of morphine sulfate (20-40 μg) were made into various subcortical regions of the rhesus monkey brain. The effects of these injections were evaluated on the nociceptive threshold as defined by the shock titration technique. The results of this preliminary investigation indicate that the region of maximal antinociceptive sensitivity to morphine in the primate is the perventricular-periaqueductal gray matter. It is tentatively suggested that morphine lowers that affective tone or the aversive component of pain by its action on the midbrain central gray and periventricular areas - both important projection and integration areas of the extralemniscal somatosensory system. © 1975.

Author-supplied keywords

  • Anatomical localization of morphine analgesia Rhesus monkey
  • Morphine
  • Periventricular-periaqueductal gray matter

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Agu Pert

  • Tony Yaksh

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free