Overcoming inhibition of antibody responses to a malaria recombinant vaccinia virus caused by prior exposure to wild type virus

  • Etlinger H
  • Altenburger W
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Abstract

Pre-injection of mice with vaccinia virus inhibited the subsequent antibody response to a recombinant polypeptide expressed by vaccinia virus. The inhibition was overcome following additional challenges with recombinant vaccinia virus. This suggests that a potential disadvantage in vaccinia-immune individuals can be circumvented and may be outweighed by the advantages of the vector. © 1991.

Author-supplied keywords

  • Recombinant vaccinia virus
  • antibody
  • exposure
  • malaria
  • wild type

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Authors

  • Howard M. Etlinger

  • Werner Altenburger

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