1. 1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice. 2. 2. This suggests that an adrenergic system normally inhibits drug induced activation and 3. 3. Points to an interaction between adrenaline and other catecholamines. © 1980.
Katz, R. J., Gelbart, J., & Carroll, B. J. (1980). Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase. Progress in Neuro-Psychopharmacology, 4(1), 101–105. https://doi.org/10.1016/0364-7722(80)90066-1