Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase

  • Katz R
  • Gelbart J
  • Carroll B
  • 2

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Abstract

1. 1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice. 2. 2. This suggests that an adrenergic system normally inhibits drug induced activation and 3. 3. Points to an interaction between adrenaline and other catecholamines. © 1980.

Author-supplied keywords

  • DOPA
  • PNMT
  • SKF 64139
  • adrenaline
  • dopamine
  • epinephrine
  • psychomotor

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Authors

  • Richard J. Katz

  • Jerry Gelbart

  • Bernard J. Carroll

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