Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase

Abstract

1. 1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice. 2. 2. This suggests that an adrenergic system normally inhibits drug induced activation and 3. 3. Points to an interaction between adrenaline and other catecholamines. © 1980.