Preparation of fluorolactones from the reaction of γ-ketoacids with diethylaminosulfur trifluoride

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Abstract

Levulinic acid and related γ-ketoacids react with diethylaminosulfur trifluoride to give γ-fluorobutyrolactones in good yield. The involvement of a bicyclic (3.2.1) mechanism is considered. © 1984.

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Patrick, T. B., & Poon, Y. F. (1984). Preparation of fluorolactones from the reaction of γ-ketoacids with diethylaminosulfur trifluoride. Tetrahedron Letters, 25(10), 1019–1022. https://doi.org/10.1016/S0040-4039(01)80089-7

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