A case of Wernicke's encephalopathy due to proven thiamine deficiency suffering from upbeat nystagmus (UN) changing to downbeat nystagmus (DN) after a latency of 1 year is presented. The case was also notable for the finding of positive oligoclonal bands in the CSF. The underlying pathophysiological mechanisms and a possible effect of baclofen treatment are discussed. © 2004 Elsevier B.V. All rights reserved.
Kastrup, O., Maschke, M., Keidel, M., & Diener, H. C. (2004). Presumed pharmacologically induced change from upbeat- to downbeat nystagmus in a patient with Wernicke’s encephalopathy. Clinical Neurology and Neurosurgery, 107(1), 70–72. https://doi.org/10.1016/j.clineuro.2003.12.006