Pre-treatment of donor with 1-deamino-8-D-arginine vasopressin could alleviate early failure of porcine xenograft in a cobra venom factor treated canine recipient

  • Hee J
  • Lee G
  • Ji Y
 et al. 
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Abstract

Objective: Unlike cardiac or renal xenotransplants, the depletion of complement using cobra venom factor (CVF) does not improve pulmonary xenograft survival. Several cases suggest that the swine von Willebrand factor (vWF) may play a major role in presenting a different pathogenesis of pulmonary xenograft dysfunction from other organs. To evaluate the role of vWF and the complement system in mediating hyperacute vascular injury of pulmonary xenografts and elucidate pathogenesis of the injury, we performed swine-to-canine orthotropic single lung xenotransplantation after pre-treatment of 1-deamino-8-d-arginine vasopressin (DDAVP) and CVF. Methods: We set up three groups for lung xenotransplantation: group I served as the control group; group II, recipients pre-treated with CVF; group III, donors pre-treated with DDAVP (9 mg/kg, 3 days)/recipients pre-treated with CVF (60 u/kg). Hemodynamic data, coagulation and complement system parameters, and grafted lung pathologies were examined serially for 3 h after transplantation. Results: DDAVP infusion reduced the vWF content in swine lung tissue in vivo (7.7±2.4 AU/mg vs 16.0±5.6 AU/mg, P

Author-supplied keywords

  • Desmopressin
  • Hyperacute rejection
  • Platelet
  • Pulmonary xenotransplantation
  • Thrombosis

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Authors

  • Jung Kang Hee

  • Gene Lee

  • Yeon Kim Ji

  • Hee Lee Seung

  • Cho Wi Hyun

  • Gyu Hwang Pil

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