Protection against collagen-induced arthritis by electrotransfer of an expression plasmid for the interleukin-4

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Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, leading to cartilage and bone destruction. We investigated whether the electrotransfer of IL-4 DNA could regulate the disease progress of murine collagen-induced arthritis (CIA). The maximum serum level of mIL-4 was measured by 340 pg/ml on day 1 following DNA transfer. The onset of severe CIA and the degree of synovitis and cartilage erosion were significantly reduced in mice treated with IL-4 DNA (P < 0.05). The beneficial effect of IL-4 gene transfer lasted for at least 17 days subsequent to treatment. The expression of IL-1β was considerably decreased in the paws by IL-4 DNA transfer (P < 0.01). On the contrary, the ratio of TIMP2 to MMP2 significantly increased in the IL-4 DNA-treated group (P < 0.01). These data demonstrated that electroporation-mediated gene transfer could provide a new approach as an IL-4 therapy for autoimmune arthritis. © 2004 Elsevier Inc. All rights reserved.

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Ho, S. H., Hahn, W., Lee, H. J., Kim, D. S., Jeong, J. G., Kim, S., … Kim, J. M. (2004). Protection against collagen-induced arthritis by electrotransfer of an expression plasmid for the interleukin-4. Biochemical and Biophysical Research Communications, 321(4), 759–766. https://doi.org/10.1016/j.bbrc.2004.07.028

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