Radical alkylation of N-alkyl 1,2,4-triazoles

  • Hansen K
  • Springfield S
  • Desmond R
 et al. 
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Reaction of 1-N-alkyl triazoles with an alkyl radical generated from the corresponding carboxylic acid, affords the triazole ring alkylated selectively in the 5 position. Secondary radicals perform best in the intermolecular reaction, while primary radicals alkylate the triazole in an intramolecular fashion. © 2001 Elsevier Science Ltd. All rights reserved.

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  • Karl B. Hansen

  • Shawn A. Springfield

  • Richard Desmond

  • Paul N. Devine

  • Edward J.J. Grabowski

  • Paul J. Reider

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