Sensory nerve depletion potentiates inhibitory non-adrenergic, non-cholinergic nerves in guinea-pig airways

  • Stretton C
  • Belvisi M
  • Barnes P
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Abstract

The effect of sensory neuropeptide depletion by systemac capsaicin pretreatment was studied both on inhibitory non-adrenergic, non-cholinergic responses elicited to electrical field stimulation and on bronchodilator responses to vasoactive intestinal peptide (the putative transmitter of these nerves), in guinea-pig trachea. Capsaicin pretreatment enhanced the relaxation responses induced by both electrical field stimulation and vasoactive intestinal peptide, whereas these responses were not significantly increased in vehicle-pretreated or in untreated animals. The bronchodilator response to isoprenaline was unaffected by capsaicin pretreatment. Sensory neuropeptide depletion therefore augments both inhibitory non-adrenergic, non-cholinergic responses and responses to exogenous vasoactive intestinal peptide, suggesting an effect on vasoactive intestinal peptide receptors. © 1990.

Author-supplied keywords

  • Airways (guinea-pig)
  • Capsaicin
  • Non-adrenergic, non-cholinergic (NANC) responses (inhibitory)

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Authors

  • C. David Stretton

  • Maria G. Belvisi

  • Peter J. Barnes

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