Serotonergic cells in nucleus raphe pallidus provide tonic drive to posterior cricoarytenoid motoneurons via 5-hydroxytryptamine2receptors in cats

  • Arita H
  • Ichikawa K
  • Sakamoto M
  • 5

    Readers

    Mendeley users who have this article in their library.
  • 30

    Citations

    Citations of this article.

Abstract

Microinjection of serotonin and 5-hydroxytryptamine2(5-HT2)agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) in nucleus ambiguus caused excitation of posterior cricoarytenoid (PCA) muscles of the larynx in anesthetized, spontaneously breathing cats. Intravenous administration of 5-HT2antagonist ketanserin produced complete block of excitatory effect of DOM injection. Electrical stimulation of nucleus raphe pallidus caused excitation of PCA activity, that was blocked by pretreatment of ketanserin. These results indicate that serotonergic cells in the-raphe pallidus provide tonic drive to medullary PCA motoneurons through 5-HT2receptors. © 1995.

Author-supplied keywords

  • 5-HT2receptor
  • Control of breathing
  • Laryngeal motoneurons
  • Medulla
  • Microinjection
  • Serotonin
  • Sleep apnea

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Hideho Arita

  • Kiyoshi Ichikawa

  • Masahiro Sakamoto

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free