Solid-phase synthesis of oxazolones and other heterocycles via Wang resin-bound diazocarbonyls

  • Yamashita M
  • Lee S
  • Koch G
 et al. 
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Abstract

The preparation of Wang resin bound α-diazo-β-ketoesters is described. These highly useful intermediates were used for the synthesis of a series of heterocycle libraries, which were obtained from the resin using TFA cleavage. In addition, a novel route for the synthesis of oxazolones using an N-H insertion strategy is disclosed. © 2005 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Diazocarbonyl
  • Heterocycles
  • Oxazolones
  • Solid-phase

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Authors

  • Makoto Yamashita

  • Sang Hyeup Lee

  • Guido Koch

  • Juerg Zimmermann

  • Bruce Clapham

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