Stereoselective hydrolysis of substituted cyclopentane diesters with pig liver esterase (PLE)

Abstract

The hydrolysis of the dimethyl meso 1,2-cyclopentanedicarboxylates 1a, 2, 3, 4a, 5a, 6a and 7a, containing various substituents at C(4) with pig liver esterase (PLE) is described. The stereoselectivity and absolute configurations of the resulting half esters were determined. In the case of substrate 2 the bicyclic lactone 10 was isolated as product. © 1993.