The descending substance P projections from the ventral medulla were studied in the rat. Electrolytic lesions which included the nucleus interfascicularis hypoglossi decrease the substance P-like immunoreactivity (SP-I) in both the intermediolateral cell column and the ventral horn of the spinal cord. Lesions of other ventral medullary areas and midbrain hemisections did not change spinal cord SP-I levels. Intracerebroventricular administration of the serotonin neurotoxin, 5,7-dihydroxytryptamine, reduced the SP-I content of the ventral horn but not of the intermediolateral cell colum. © 1982.
Helke, C. J., Neil, J. J., John Massari, V., & Loewy, A. D. (1982). Substance P neurons project from the ventral medulla to the intermediolateral cell column and ventral horn in the rat. Brain Research, 243(1), 147–152. https://doi.org/10.1016/0006-8993(82)91128-3