Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity

  • Minutolo F
  • Bertini S
  • Betti L
 et al. 
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Abstract

Stable analogues of farnesyl diphosphate, possessing an aniline-type portion in the prenyl-mimic moiety and phosphonoacetamido(oxy) groups in the place of the metabolically unstable diphosphate unit, were synthesised and submitted to biological assays. The enzyme inhibition tests performed on FTase and GGTase I show that the newly synthesised compounds based on a combination of the aniline-containing portions with (phosphonoacetamido)oxy groups do not afford potent inhibitors. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.

Author-supplied keywords

  • Aniline
  • FTase
  • Farnesyldiphosphate
  • Hexafluoroaniline
  • Phosphonoacetamido(oxy)

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Authors

  • Filippo Minutolo

  • Simone Bertini

  • Laura Betti

  • Valeria Di Bussolo

  • Gino Giannaccini

  • Giorgio Placanica

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