Synthesis of a bipolar phosphatidylethanolamine: A model compound for a membrane-spanning probe

  • Delfino J
  • Stankovic C
  • Schreiber S
 et al. 
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Abstract

A general strategy for the synthesis of membrane-spanning bipolar phospholipids equipped with a reactive functional group probe of the membrane environment is described. The strategy is exemplified by the synthesis of a bisphosphatidylethanolamine that is connected through a benzylidene thioacetal of the ω-hydroxy esters at the sn-2 position of the two phosphoglycerol termini. © 1987.

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Authors

  • Jose M. Delfino

  • Charles J. Stankovic

  • Stuart L. Schreiber

  • Frederic M. Richards

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