A general strategy for the synthesis of membrane-spanning bipolar phospholipids equipped with a reactive functional group probe of the membrane environment is described. The strategy is exemplified by the synthesis of a bisphosphatidylethanolamine that is connected through a benzylidene thioacetal of the ω-hydroxy esters at the sn-2 position of the two phosphoglycerol termini. © 1987.
Delfino, J. M., Stankovic, C. J., Schreiber, S. L., & Richards, F. M. (1987). Synthesis of a bipolar phosphatidylethanolamine: A model compound for a membrane-spanning probe. Tetrahedron Letters, 28(21), 2323–2326. https://doi.org/10.1016/S0040-4039(00)96114-8