Synthesis of erythro and threo furanoid glycals from 1- and 2-phenylselenenyl-carbohydrate derivatives

  • Bravo F
  • Kassou M
  • Díaz Y
 et al. 
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Abstract

Differently protected erythro and threo furanoid glycals were synthesized by selenoxide elimination when phenyl 1-selenoglycosides were treated in oxidizing conditions (tBuOOH, Ti(OiPr)4, Et2iPrN). The phenyl 1-selenoglycosides were obtained from methyl 2-deoxy-D-erythro-pentofuranoside by protection of the primary hydroxyl or both hydroxyls and further reaction with PhSeH in the presence of BF3·Et2O. Erythro and threo furanoid glycals were also prepared by treating 2-deoxy-2-phenylselenenyl-1,4-anhydrocyclitols under similar conditions. The 2-deoxy-2-phenylselenenyl-1,4-anhydrocyclitols were obtained from 4-pentene-1,2,3-triols by a 5-endo selenium electrophilic induced cyclization. © 2001 Published by Elsevier Science Ltd.

Author-supplied keywords

  • 1,4-Anhydro-2-phenylselenenyl-pentitols
  • Double bond formation
  • Glycal synthesis
  • Selenoglycosides
  • Selenoxide elimination

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