The design of haptens to generate antibodies with the potential to catalyse carbanionic cyclisation reactions is introduced in the context of Dieckmann cyclisations and related reactions. Syntheses of five-membered ring haptens containing a sulphone, to represent the transition state(s) associated with the tetrahedral intermediate, and an amino group, to promote the formation of a general base, are described. Results with partially purified antibodies are reported showing that the target reaction can be catalysed by antibodies. © 1995 Elsevier Science Ltd.
Currie, M., Suckling, C. J., Zhu, L. min, Irvine, J., & Stimson, W. H. (1995). The Synthesis of Haptens and Properties of Catalytic Antibodies Designed to Catalyse Carbanionic Cyclisation Reactions. Tetrahedron, 51(32), 8915–8922. https://doi.org/10.1016/0040-4020(95)00500-8