The Synthesis of Haptens and Properties of Catalytic Antibodies Designed to Catalyse Carbanionic Cyclisation Reactions

  • Currie M
  • Suckling C
  • Zhu L
 et al. 
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The design of haptens to generate antibodies with the potential to catalyse carbanionic cyclisation reactions is introduced in the context of Dieckmann cyclisations and related reactions. Syntheses of five-membered ring haptens containing a sulphone, to represent the transition state(s) associated with the tetrahedral intermediate, and an amino group, to promote the formation of a general base, are described. Results with partially purified antibodies are reported showing that the target reaction can be catalysed by antibodies. © 1995 Elsevier Science Ltd.

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