Synthesis and photosynthetic inhibition activity of substituted 5-(bis-trifluoromethyl)methyl)-2-aminothiazoles

  • Boyer C
  • Finazzi G
  • Laurent P
 et al. 
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Abstract

The reaction of 5,5,5-trifluoro-4-trifluoromethyl-pent-3-en-2-one with aminothiocarbonyls yielded aminothiourea precursors which readily cyclised to the corresponding thiazole derivatives, 5-(bis-trifluoromethyl)methyl)-2-aminothiazoles. The inhibitory potency of photosystem II activity of these thiazoles was evaluated using fluorescence measurement techniques. Two of the compounds showed a good activity in comparison with the reference compound DCMU, 3-(3,4-dichlorophenol)-1,1-dimethylurea. Calculation of lipophilicity according to Rekker and Frey, and a corresponding experimental determination are reported. © 2006 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • 2-Aminothiazole
  • DCMU
  • Fluorescence
  • Gem bis-trifluoromethylated molecules
  • Lipophilicity
  • PS II inhibitor

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Authors

  • Cécile Boyer

  • Giovanni Finazzi

  • Philippe Laurent

  • Alois Haas

  • Hubert Blancou

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