Synthesis, resolution, and applications of 3-amino-2,2-dimethyl-1,3- diphenylpropan-1-ol, a conformationally restricted 1,3-aminoalcohol

  • Patil M
  • Gonnade R
  • Joshi N
  • 2


    Mendeley users who have this article in their library.
  • 12


    Citations of this article.


Efficient synthetic routes to both syn and anti diastereomers of a conformationally restricted 1,3-aminoalcohol were devised. Resolution of the aminoalcohols was accomplished through diastereomeric salt with R-(-)-O-acetyl mandelic acid. These aminoalcohols were examined as ligands for two standard reactions, namely, enantioselective addition of Et2Zn to aldehydes and reduction of prochiral ketones with BH3. © 2010 Elsevier Ltd.

Author-supplied keywords

  • 1,3-Aminoalcohol
  • Aldol-Tishchenko reaction
  • Diethylzinc
  • Oxazaborinane
  • Resolution

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • M. N. Patil

  • R. G. Gonnade

  • N. N. Joshi

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free