Traceless solid-phase synthesis of 2-amino-5-alkylidene-thiazol-4-ones

  • Pulici M
  • Quartieri F
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2-Amino-5-alkylidene-thiazol-4-ones bearing two diversity points are prepared by a solid-phase strategy exploiting rhodanine as the starting material. Rhodanine is first loaded on bromo-Wang resin, subjected to Knovenagel condensation with aldehydes, and cleaved off the resin in a traceless manner by means of an amine. © 2005 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Knovenagel reaction
  • Solid-phase synthesis
  • Thiazolone
  • Traceless linker

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  • Maurizio Pulici

  • Francesca Quartieri

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