α-methylene β-amino phosphonic ester derivatives by amination of (1-trimethylsilanylmethyl-vinyl) phosphonic esters

Abstract

(1-Trimethylsilanylmethyl-vinyl)-phosphonic esters are synthesised via Wittig-Horner reactions starting from methylenediphosphonic esters. The reactions of (1-trimethylsilanylmethyl-vinyl)-phosphonic esters with NsONHCO2Et and CaO, produce α-methylene N-(ethoxycarbonyl) β-amino phosphonic esters, isolated up to 60% yield, through addition of (ethoxycarbonyl) amine function on the double bond and silyl group elimination. © 2001 Elsevier Science Ltd.