The method of single quantum 13C editing is analyzed and implemented with water suppressed J-refocused coherence transfer spectroscopy. Analysis of the 13C inversion pulse demonstrates that it is optimally placed into the second echo of the J-refocused sequence. We have used this method to acquire 13C-edited spectra of glutamate from phantoms and in vivo. The turnover of 13C4-labeled glutamate in human brain in vivo was observed in parasagittal gray matter using a volume head coil at 4.1 T with a time resolution of 5.3 min.
CITATION STYLE
Pan, J. W., Mason, G. F., Vaughan, J. T., Chu, W. J., Zhang, Y., & Hetherington, H. P. (1997). 13C editing of glutamate in human brain using J-refocused coherence transfer spectroscopy at 4.1 T. Magnetic Resonance in Medicine, 37(3), 355–358. https://doi.org/10.1002/mrm.1910370308
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