The use of 1H NMR experiments to determine the solubility of potential drug candidates using a panel of solubilizing agents is proposed as an alternative to an HPLC-UV method. The advantages of using this approach will be discussed and results comparing the two methodologies will be presented. This effort highlights the importance of a simple method for determining a suitable formulation for discovery compounds for studies using a minimal amount of material in support of early in vivo studies. © 2008 Elsevier B.V. All rights reserved.
CITATION STYLE
Lin, M., Tesconi, M., & Tischler, M. (2009). Use of 1H NMR to facilitate solubility measurement for drug discovery compounds. International Journal of Pharmaceutics, 369(1–2), 47–52. https://doi.org/10.1016/j.ijpharm.2008.10.038
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