Use of 1H NMR to facilitate solubility measurement for drug discovery compounds

  • Lin M
  • Tesconi M
  • Tischler M
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Abstract

The use of 1H NMR experiments to determine the solubility of potential drug candidates using a panel of solubilizing agents is proposed as an alternative to an HPLC-UV method. The advantages of using this approach will be discussed and results comparing the two methodologies will be presented. This effort highlights the importance of a simple method for determining a suitable formulation for discovery compounds for studies using a minimal amount of material in support of early in vivo studies. © 2008 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • 1H NMR
  • Formulation
  • HPLC-UV
  • In vivo studies
  • Solubility studies

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Authors

  • Melissa Lin

  • Marc Tesconi

  • Mark Tischler

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