A 3D simulation of in vitro epithelial to mesenchymal transition (EMT) is presented. The simulation uses Compucell3D to realize a cellular Potts model of this process. The purpose of the model is to test the hypothesis that EMT can be achieved through a combination of a) the loss of endocardial cohesion; and b) a gain of endocardial to extracellular matrix adhesion. The results of the simulation demonstrate confirmation of the hypothesis. A mechanism by which EMT could be regulated by mitosis is demonstrated. Further, the implication of the study to heart development is explored. © 2011 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Summers, R., Abdulla, T., Imms, R. A., & Schleich, J. M. (2011). 3D simulation of an in vitro epithelial to mesenchymal transition. In IFMBE Proceedings (Vol. 37, pp. 1287–1290). Springer Verlag. https://doi.org/10.1007/978-3-642-23508-5_333
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