Journal article

3D Simulation of an in vitro Epithelial to Mesenchymal Transition

Summers R, Abdulla T, Imms R, Schleich J ...see all

5th European IFMBE Conference, IFMBE Proceedings 37 (2011) pp. 1287-1290

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A 3D simulation of in vitro epithelial to mesen- chymal transition (EMT) is presented. The simulation uses Compucell3D to realize a cellular Potts model of this process. The purpose of the model is to test the hypothesis that EMT can be achieved through a combination of a) the loss of endo- cardial cohesion; and b) a gain of endocardial to extracellular matrix adhesion. The results of the simulation demonstrate confirmation of the hypothesis. A mechanism by which EMT could be regulated by mitosis is demonstrated. Further, the implication of the study to heart development is explored.

Author-supplied keywords

  • cellular potts
  • ggh
  • heart
  • multiscale

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  • Ron Summers

  • Tariq Abdulla

  • Ryan a Imms

  • Jean-Marc Schleich

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