The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages

  • De La Llera-Moya M
  • Drazul-Schrader D
  • Asztalos B
 et al. 
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Abstract

We measured efflux from macrophages to apolipoprotein B-depleted serum from 263 specimens and found instances in which serum having similar high-density lipoprotein cholesterol (HDL-C) differed in their efflux capacity. Thus, we wanted to elucidate why efflux capacity could be independent of total HDL-C or apolipoprotein A-I (apoA-I).

Author-supplied keywords

  • ABCA1
  • Apolipoprotein A-I
  • Cholesterol efflux
  • High-density lipoprotein cholesterol
  • Macrophages

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Authors

  • Daniel RaderPerelman School of Medicine at the University of Pennsylvania

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  • Margarita De La Llera-Moya

  • Denise Drazul-Schrader

  • Bela F. Asztalos

  • Marina Cuchel

  • George H. Rothblat

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