Accuracy of the 'Paedfusor' in children undergoing cardiac surgery or catheterization

  • Absalom A
  • Amutike D
  • Lal A
 et al. 
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Abstract

BACKGROUND: A prototype paediatric propofol target-controlled infusion (TCI) system, the 'Paedfusor' has been developed. This system incorporates a paediatric pharmacokinetic data set and algorithm specific for children in a Graseby 3500 anaesthesia syringe driver. In this study we have evaluated the accuracy of the Paedfusor TCI system in children who underwent either cardiac surgery or cardiac catheterization procedures. METHODS: Twenty-nine children aged 1-15 yr were investigated. General anaesthesia was provided using propofol administered by the Paedfusor system. Accuracy of the system was evaluated by obtaining up to 9 arterial samples for measurement of propofol concentration both during anaesthesia and in the recovery period. Measured arterial propofol concentrations were then compared with values calculated by the Paedfusor. RESULTS: The predictive indices of median performance error (MDPE), and median absolute performance error (MDAPE) of the Paedfusor system were found to be 4.1% and 9.7%, respectively and the median value for wobble was 8.3%. These values are much better than those found with the adult 'Diprifusor' system. CONCLUSION: The Paedfusor performance was found to be within the accepted limits for use as a TCI system.

Author-supplied keywords

  • Anaesthetic techniques, i.v.
  • Anaesthetic techniques, i.v. infusions
  • Anaesthetics i.v., propofol
  • Pharmacokinetics
  • Surgery, cardiovascular

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Authors

  • Anthony Absalom

  • D. Amutike

  • A. Lal

  • M. White

  • G. N C Kenny

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