Age at graft loss after pediatric kidney transplantation: Exploring the high-risk age window

  • Van Arendonk K
  • James N
  • Boyarsky B
 et al. 
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Abstract

BACKGROUND AND OBJECTIVE: The risk of graft loss after pediatric kidney transplantation increases during late adolescence and early adulthood, but the extent to which this phenomenon affects all recipients is unknown. This study explored interactions between recipient factors and this high-risk age window, searching for a recipient phenotype that may be less susceptible during this detrimental age interval.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: With use of Scientific Registry of Transplant Recipients data from 1987 to 2010, risk of graft loss across recipient age was quantified using a multivariable piecewise-constant hazard rate model with time-varying coefficients for recipient risk factors.

RESULTS: Among 16,266 recipients, graft loss during ages ≥17 and
CONCLUSIONS: No recipient subgroups are exempt from the dramatic increase in graft loss during late adolescence and early adulthood, a high-risk window that modifies the relationship between typical recipient risk factors and graft loss.

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Authors

  • Kyle J. Van Arendonk

  • Nathan T. James

  • Brian J. Boyarsky

  • Jacqueline M. Garonzik-Wang

  • Babak J. Orandi

  • John C. Magee

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