Alendronate in the treatment of low bone mass in steroid-treated boys with Duchenne's muscular dystrophy.

  • GA H
  • Ridout R
  • VA H
 et al. 
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OBJECTIVE: To examine alendronates side-effect profile and effect on bone mineral density (BMD) in deflazacort-treated boys with Duchennes muscular dystrophy (DMD) and low BMD. DESIGN: Before-after trial. SETTING: Neuromuscular clinic at a children's hospital in Canada between 1999 and 2000. PARTICIPANTS: All consenting boys with DMD who had z scores less than -1.00 (spine and/or total body) and in whom BMD testing was feasible. INTERVENTION: Boys received .08 .d(-1) of alendronate orally, with 750 mg of daily calcium and 1000 IU of vitamin D. BMD, height, weight, physical activity, Tanner stage, and adverse effects were followed for 2 years. MAIN OUTCOME MEASURES: BMD z scores at the lumbar spine (L1-4) and total body. RESULTS: Of the 42 eligible boys assessed, 23 had low BMD; for 16 of the 23, future BMD testing was feasible. Mean age was 10.8 years (range, 6.9-15.6 y). Mean baseline z scores at the total body and spine were -0.80 and -1.94, respectively. At 2 years, mean z scores were unchanged. Furthermore, alendronate response varied by baseline age. In multivariable analysis, improvement in total body and spine z scores was associated with younger age at baseline ( P =.01 for both). CONCLUSIONS: In deflazacort-treated boys, alendronate had a positive effect on BMD z scores; the effect was greatest when given early in the course of disease. Copyright © 2005 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation

Author-supplied keywords

  • Adolescence
  • Alendronate -- Therapeutic Use
  • Bone Density -- Drug Effects
  • Child
  • Descriptive Statistics
  • Funding Source
  • Glucocorticoids -- Therapeutic Use
  • Human
  • Linear Regression
  • Male
  • Muscular Dystrophy, Duchenne -- Drug Therapy
  • Spearman's Rank Correlation Coefficient
  • Treatment Outcomes

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  • Hawker GA

  • R Ridout

  • Harris VA

  • Chase CC

  • Fielding LJ

  • Biggar WD

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