Analgesic and anticonvulsant effects of Acorus calamus roots in mice

Abstract

Acorus calamus has been used for a long time in traditional medicine as a remedy for pain, convulsion, inflammation, and ulcer. In the present work, the analgesic effects of methanolic extract of Acorus calamus roots (MEAC) have been evaluated using acetic acid induced Writhing response and Rat caudal immersion method. Whereas the anticonvulsant effect were investigated by utilizing pentylenetetrazol induced convulsion methods. MEAC administered orally at the doses of 100 and 200 mg/kg, exhibited protective effect against the pain models in mice. Also the methanolic extract of Acorus calamus roots significantly increased the latency period in seizures induced by PTZ in mice. These obtained results indicate the analgesic as well as anticonvulsant effect Acorus calamus roots.