αI domain integrins have been found in the ascidian Ciona intestinalis. We produced Ciona α1I domain as a recombinant protein. It did not recognize fibril-forming collagens or bind to GFOGER or other similar motifs in triple-helical peptides. No GFOGER motifs were found in Ciona collagens. As Ciona α1I bound to collagen IX, we propose that before the emergence of GFOGER-dependent collagen receptors in vertebrates, αI domain integrins might have been able to bind to collagen with alternative mechanisms. © 2007 Federation of European Biochemical Societies.
CITATION STYLE
Tulla, M., Huhtala, M., Jäälinoja, J., Käpylä, J., Farndale, R. W., Ala-Kokko, L., … Heino, J. (2007). Analysis of an ascidian integrin provides new insight into early evolution of collagen recognition. FEBS Letters, 581(13), 2434–2440. https://doi.org/10.1016/j.febslet.2007.04.054
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