When having a continuous free choice in their home cages between water and alcohol- or drug-containing drinking solutions, rats first develop a controlled consumption of the psychotropic compound and, after several months, lose their control over drug taking. After a long period of abstinence, they reveal an excessive, compulsive drug intake. Adulteration of the drug-containing solutions reduces the doses taken by controlled consumers, but not those of the excessive drinkers, they can therefore be regarded as addicted. These animals show a pre-intake motor restlessness that may be related to craving. In two studies with putative anti-craving agents (the dopamine D2 receptor agonist lisuride and the D2 receptor antagonist flupentixol) we treated alcohol-addicted and non-addicted rats and observed the effects on alcohol taking, alcohol seeking and brain neurotransmission. These two investigations paralleled clinical studies, in both cases the results could be predicted correctly ('pro-craving' effect of both pharmaceutics). Differences between 'symptomatic' and possible 'causal' therapies are discussed, approaches towards a causal therapy according to an 'imprinting'-model of an addition are suggested.
CITATION STYLE
Wolffgramm, J., Galli, G., Thimm, F., & Heyne, A. (2000). Animal models of addiction: Models for therapeutic strategies? Journal of Neural Transmission, 107(6), 649–668. https://doi.org/10.1007/s007020070067
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