Antimicrobial abietane diterpenoids from Plectranthus elegans

  • Dellar J
  • Cole M
  • Waterman P
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Abstract

Two novel abietane diterpenoids have been isolated from the aerial material of Plectranthus elegans and identified as 11-hydroxy-12-oxo-7,9(11),13-abietatriene and 7α,11-dihydroxy-12-methoxy-8,11,13-abietatriene. Their structures were determined through rigorous use of spectroscopic methods. Both inhibited spore germination of the fungus Cladosporium cucumerinum, in direct bioautography, at a dose of 1 μg. The new diterpenes also inhibited the growth of Gram-positive bacteria, in the concentration range 10-40 μg ml-1in broth dilution assay. No effect was observed against Gram-negative bacteria. The ecological implications of these findings are discussed. Copyright © 1996 Elsevier Science Ltd. All rights reserved.

Author-supplied keywords

  • Abietane diterpenoids
  • Antibacterial activity
  • Antifugal activity
  • Lamiaceae
  • Plectranthus elegans

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Authors

  • Joanne E. Dellar

  • Michael D. Cole

  • Peter G. Waterman

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