The application of genomic and molecular data in the treatment of chronic cancer pain

  • Turabi A
  • Plunkett A
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Abstract

Many cancer patients will develop complex pain syndromes requiring aggressive, innovative, and comprehensive multimodal pain management strategies. Recently, data from both animal studies and clinical trials have allowed clinical research to focus on creating applicable clinical treatment strategies. This article is a review of genomic and molecular data, which has contributed to creating novel modalities for use in clinical pain management of patients with cancer-induced pain.

Author-supplied keywords

  • *Polymorphism, Single Nucleotide/drug effects
  • Analgesics/*therapeutic use
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal/therapeuti
  • Anticonvulsants/therapeutic use
  • Antidepressive Agents/therapeutic use
  • Antineoplastic Agents/administration & dosage/*adv
  • Autonomic Nerve Block
  • Catechol O-Methyltransferase/genetics
  • Chronic Disease
  • Genetic Therapy/*methods/trends
  • Humans
  • N-Methylaspartate/antagonists & inhibitors
  • Neoplasms/*complications/drug therapy
  • Pain Management/*methods
  • Pain/chemically induced/*etiology/genetics/*physio
  • Receptors, Opioid, mu/genetics
  • Somatosensory Cortex/drug effects
  • Translational Medical Research/trends

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Authors

  • A Turabi

  • A R Plunkett

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