Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.

  • Sery O
  • Hlinecka L
  • Povova J
 et al. 
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Dementias of old age, in particular Alzheimer's disease (AD), pose a growing threat to the longevity and quality of life of individuals as well as whole societies world-wide. The risk factors are both genetic and environmental (life-style) and there is an overlap with similar factors predisposing to cardiovascular diseases (CVD). Using a case-control genetic approach, we have identified a SNP (rs10507391) in ALOX5 gene, previously associated with an increased risk of stroke, as a novel genetic risk factor for AD. ALOX5 gene encodes a 5'-lipoxygenase (5'-LO) activating protein (FLAP), a crucial component of the arachidonic acid/leukotriene inflammatory cascade. A-allele of rs4769874 polymorphism increases the risk of AD 1.41-fold (p

Author-supplied keywords

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Arachidonate 5-Lipoxygenase
  • Body Mass Index
  • Body Weight
  • Czech Republic
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Life Style
  • Male
  • Polymorphism, Single Nucleotide
  • Surveys and Questionnaires
  • genetics
  • physiopathology
  • psychology

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  • Omar Sery

  • Lydia Hlinecka

  • Jana Povova

  • Ondrej Bonczek

  • Tomas Zeman

  • Vladimir Janout

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