An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults

  • Rosenberg R
  • Caron J
  • Roth T
 et al. 
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Abstract

Background and purpose: This randomized, double-blind, placebo-controlled study assessed the efficacy and safety of eszopiclone, a non-benzodiazepine hypnotic agent, in healthy adults using the first-night effect model of transient insomnia. Patients and methods: A total of 436 healthy, normal sleeping participants were randomized to receive either eszopiclone 1, 2, 3, or 3.5 mg, or placebo. Efficacy and next-morning effects were evaluated via polysomnography (PSG), Digit Symbol Substitution Test (DSST), and self-report. Results: Patients treated with eszopiclone had significant ly less PSG latency to persistent sleep (all doses except 1 mg; P≤0.0001), wake time after sleep onset (all doses; P≤0.05) and number of awakenings (3 and 3.5 mg doses; P

Author-supplied keywords

  • Eszopiclone
  • Non-benzodiazepine
  • Sleep initiation and maintenance disorder
  • Transient insomnia

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Authors

  • Russell Rosenberg

  • Judy Caron

  • Thomas Roth

  • David Amato

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