Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: An integrated analysis

  • MacGregor S
  • Lind P
  • Bucholz K
 et al. 
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Abstract

Alcohol dependence (AD) is a complex disorder with environmental and genetic origins. The role of two genetic variants in ALDH2 and ADH1B in AD risk has been extensively investigated. This study tested for associations between nine polymorphisms in ALDH2 and 41 in the seven ADH genes, and alcohol-related flushing, alcohol use and dependence symptom scores in 4597 Australian twins. The vast majority (4296) had consumed alcohol in the previous year, with 547 meeting DSM-IIIR criteria for AD. There were study-wide significant associations (P

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Authors

  • Stuart MacGregor

  • Penelope A. Lind

  • Kathleen K. Bucholz

  • Narelle K. Hansell

  • Pamela A.F. Madden

  • Melinda M. Richter

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