Atopic eczema (AE) is a chronic inflammatory skin disease that is mainly characterized by pruritus and epidermal barrier dysfunction. Between 15% and 20% of children and 1%-3% of adults are affected worldwide. AE is a complex disease triggered by multiple triggers, including gene and environmental factors. Impaired skin barrier function, modifications of the immune system, and hyper-reactivity to environmental stimulation directly cause and aggravate AE. In this review, we provide an overview of the recent developments and future directions in the pathogenesis of AE.
CITATION STYLE
Mao, W., Mao, J., Zhang, J., Wang, L., Cao, D., & Qu, Y. (2014, January 1). Atopic eczema: A disease modulated by gene and environment. Frontiers in Bioscience - Landmark. Bioscience Research Institute. https://doi.org/10.2741/4237
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