Auditory and visual P300 reflecting cognitive improvement in patients with schizophrenia with quetiapine: A pilot study

  • Park E
  • Han S
  • Jeon Y
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Abstract

We recorded event-related potentials (ERPs) in patients with schizophrenia before and after treatment with quetiapine, to investigate this drug's effects on cognitive function. Auditory and visual oddball stimulus discrimination paradigms were presented to patients with schizophrenia (N=20) before and after 3. months' treatment with quetiapine. The 2-stimulus auditory oddball paradigm used a standard tone (1000. Hz, 75. dB, 80%) and a target tone (2000. Hz, 75. dB, 20%). The 2-stimulus visual oddball paradigm used a standard stimulus (small circle, 80%) and a target stimulus (large circle, 20%). Patients' severity of psychopathology was initially evaluated with the Positive and Negative Syndrome Scale (PANSS) and was likewise re-evaluated after treatment. After treatment with quetiapine, patients' P300 amplitudes increased over baseline for both tasks (auditory stimuli, P

Author-supplied keywords

  • Cognitive function
  • P300
  • Quetiapine
  • Schizophrenia
  • Symptom

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Authors

  • E. Jin Park

  • Sang Ick Han

  • Yang Whan Jeon

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