BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy.[Erratum appears in Circulation 2002 Sep 24;106(13):1743]

  • Gottlieb S
  • Brater D
  • Thomas I
 et al. 
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BACKGROUND: Adenosine may adversely affect renal function via its effects on renal arterioles and tubuloglomerular feedback, but effects of adenosine blockade in humans receiving furosemide and ACE inhibitors is unknown. METHODS AND RESULTS: This was a randomized, double-blind, ascending-dose, crossover study evaluating 3 doses of BG9719 in 63 patients with congestive heart failure. Patients received placebo or 1 of 3 doses of BG9719 on 1 day and the same medication plus furosemide on a separate day. Renal function and electrolyte and water excretion were assessed. BG9719 alone caused an increase in urine output and sodium excretion (P

Author-supplied keywords

  • *Diuresis/de [Drug Effects]
  • *Diuretics/ae [Adverse Effects]
  • *Furosemide/ae [Adverse Effects]
  • *Glomerular Filtration Rate/de [Drug Effects]
  • *Purinergic P1 Receptor Antagonists
  • *Xanthines/tu [Therapeutic Use]
  • 0 (1,3-dipropyl-8-(2-(5,6-epoxy)norbornyl)xanthine
  • 0 (Angiotensin-Converting Enzyme Inhibitors)
  • 0 (Diuretics)
  • 0 (Drug Combinations)
  • 0 (Electrolytes)
  • 0 (Purinergic P1 Receptor Antagonists)
  • 0 (Xanthines)
  • 7LXU5N7ZO5 (Furosemide)
  • 9NEZ333N27 (Sodium)
  • AYI8EX34EU (Creatinine)
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors/pd [Pharm
  • Blood Pressure/de [Drug Effects]
  • Creatinine/bl [Blood]
  • Creatinine/ur [Urine]
  • Cross-Over Studies
  • Diuretics/tu [Therapeutic Use]
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Combinations
  • Electrolytes/ur [Urine]
  • Female
  • Furosemide/tu [Therapeutic Use]
  • Heart Failure/dt [Drug Therapy]
  • Heart Rate/de [Drug Effects]
  • Humans
  • Male
  • Middle Aged
  • Sodium/ur [Urine]
  • Urinalysis
  • Xanthines/bl [Blood]

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  • S S Gottlieb

  • D C Brater

  • I Thomas

  • E Havranek

  • R Bourge

  • S Goldman

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