Biochemistry to the Rescue: A ClC-2 Auxiliary Subunit Provides a Tangible Link to Leukodystrophy

  • Maduke M
  • Reimer R
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ClC-2 is a broadly distributed chloride channel with an enigmatic neurophysiological function. In this issue of Neuron, Jeworutzki et al. (2012) use a biochemical approach to identify GlialCAM, a protein with a defined link to leukodystrophy, as a ClC-2 auxiliary subunit. © 2012 Elsevier Inc.

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