The birthdates of GABA-immunoreactive amacrine cells in the rat retina

  • Lee M
  • Shin S
  • Han S
 et al. 
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Abstract

The birthdates of GABAergic amacrine cells in the rat retina were investigated by immunocytochemistry using anti-GABA and anti-bromodeoxyuridine (BrdU) antisera. The ratio of co-localization of GABA to BrdU increased gradually from embryonic-day 13 (E13) and showed a peak value on E18 in the central retina and on E20 in the periphery. After birth, until postnatal-day 3 (P3), a few co-localized cells were observed in the inner nuclear layer (INL). However, in the peripheral retina, co-localized cells were observed in the INL and ganglion cell layer until P5. Our results suggest that the birthdates of GABA-immunoreactive cells vary, depending on cell-type and that there is a temporal lag in the GABA-immunoreactive cell production in the peripheral retina relative to the central retina.

Author-supplied keywords

  • Bromodeoxyuridine
  • GABA
  • Immunohistochemistry
  • Proliferation
  • Rat
  • Retina

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Authors

  • M. Y. Lee

  • S. L. Shin

  • S. H. Han

  • M. H. Chun

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