Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

  • Harikrishnan K
  • Chow M
  • Baker E
 et al. 
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Abstract

Transcriptional repression of methylated genes can be mediated by the methyl-CpG binding protein MeCP2. Here we show that human Brahma (Brm), a catalytic component of the SWI/SNF-related chromatin-remodeling complex, associates with MeCP2 in vivo and is functionally linked with repression. We used a number of different molecular approaches and chromatin immunoprecipitation strategies to show a unique cooperation between Brm, BAF57 and MeCP2. We show that Brm and MeCP2 assembly on chromatin occurs on methylated genes in cancer and the gene FMR1 in fragile X syndrome. These experimental findings identify a new role for SWI/SNF in gene repression by MeCP2.

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Authors

  • K. N. Harikrishnan

  • Maggie Z. Chow

  • Emma K. Baker

  • Sharmistha Pal

  • Sahar Bassal

  • Daniella Brasacchio

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